Improvement of DNA repair in lymphocytes of breast cancer patients treated with Viscum album extract (Iscador)

European Journal of Cancer and Clinical Oncology Pub Date : 1991-12-01 DOI:10.1016/0277-5379(91)90443-H

Eva Kovacs , Tibor Hajto , Katerina Hostanska

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引用次数: 42

Abstract

We investigated alteration in DNA repair during therapy with an immunomodulator. 14 patients with advanced breast cancer were treated parenterally with Iscador, an extract of Viscum album (mistletoe). As a parameter for measurement of DNA repair the incorporation of (³H) thymidine into DNA of unstimulated lymphocytes after ultra violet light (UV) damage was taken. The DNA repair values in the patients were very low before treatment and on day 1: on average 16% of those in a healthy control population. Values started to increase on day 2 and on days 7–9 were on average 2.7 times higher than before treatment. $1214$ patients showed an improvement in repair. The values of spontaneous DNA synthesis were not altered during the treatment. We suggest that the increase of DNA repair could be due to a stimulation of repair enzymes by lymphokines or cytokines secreted by activated leukocytes or an alteration in the susceptibility to exogenic agents resulting in less damage.

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visum album提取物对乳腺癌患者淋巴细胞DNA修复的改善作用

我们研究了免疫调节剂治疗期间DNA修复的改变。采用槲寄生提取物Iscador对14例晚期乳腺癌患者进行肠外治疗。以(3H)胸苷在紫外线损伤后未受刺激的淋巴细胞DNA中的掺入量作为测量DNA修复的参数。患者的DNA修复值在治疗前和第1天非常低:平均为健康对照人群的16%。第2天开始升高，第7-9天平均为治疗前的2.7倍。1214例患者出现修复改善。自发性DNA合成值在治疗期间未发生改变。我们认为，DNA修复的增加可能是由于被激活的白细胞分泌的淋巴因子或细胞因子刺激了修复酶，或者对外源性药物的易感性发生了改变，从而减少了损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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European Journal of Cancer and Clinical Oncology

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