ras p21 expression in relation to DNA ploidy, S-phase fraction and prognosis in colorectal adenocarcinoma

European Journal of Cancer and Clinical Oncology Pub Date : 1991-12-01 DOI:10.1016/0277-5379(91)90437-I

Xiao-Feng Sun , Sten Wingren , John M. Carstensen , Olle Stål , Thomas Hatschek , Bernt Boeryd , Bo Nordenskjöld , Hong Zhang

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引用次数: 16

Abstract

ras p21 expression, as indicated by the monoclonal antibody ras 11, was estimated using immunohistochemistry on 69 primary colorectal adenocarcinomas. Also, DNA ploidy and S-phase fraction (SPF) were analysed with flow cytometry. Positive staining for ras 11 tended to be more common in DNA non-diploid tumours (P = 0.11), but was significantly correlated with high SPF (P = 0.038). Positive ras 11 staining, Dukes' stage, DNA ploidy and SPF were related to the recurrence-free interval of patients with Dukes' A–C tumours (P = 0.0014, P = 0.023, P = 0.035 and P = 0.040, respectively). ras 11 staining was a prognostic factor independent of both Dukes' stage and DNA ploidy (P = 0.011). The results indicate that pan ras p21 expression is associated with proliferative activity and has an independent prognostic value in colorectal adenocarcinoma.

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ras p21表达与DNA倍体、s期分数及结直肠癌预后的关系

通过单克隆抗体Ras 11，利用免疫组化技术估计了69例原发性结直肠癌中Ras p21的表达。流式细胞术检测DNA倍性和s期分数(SPF)。ras 11阳性染色在DNA非二倍体肿瘤中更为常见(P = 0.11)，但与高SPF值显著相关(P = 0.038)。ras 11阳性染色、Dukes分期、DNA倍性和SPF值与Dukes A-C肿瘤无复发间隔相关(P = 0.0014、P = 0.023、P = 0.035、P = 0.040)。ras 11染色与Dukes分期和DNA倍性无关(P = 0.011)。结果表明，pan ras p21的表达与结直肠癌的增殖活性相关，且在结直肠癌中具有独立的预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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European Journal of Cancer and Clinical Oncology

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