[Evaluation of biological effectiveness of high-energy accelerated particles based on the study of cytogenetic disorders in murine sex cells].

Abstract

The frequency of reciprocal translocations in spermatogonia of F1(CBAxC57Bl6) mice irradiated with 50 MeV protons, 4.2 GeV deuterons, 1.8 GeV/nucleon helium ions or 60Co gamma-rays was investigated. The relative biological effectiveness of these particles calculated by comparing the equieffective doses of reference and experimental radiations was less than 1.0 under the assumption of the linear dose-effect relationship. The RBE of the particles calculated by means of the nonparametric method largely depended on the doses applied.