Antibacterial evaluation of Spray Gel Formula of Angsana Leaf Extract (Pterocarpus indicus Willd.) Using Combination Base of Carbopol 940 and HPMC

Abstract

The 70% ethanol extract of 70% angsana leaves known have antibacterial activity. The aim of this study was to determine the inhibitory activity produced by a spray gel using a combination base of carbopol 940 and HPMC against Staphylococcus aureus as one of bacteria causes of skin infections. In this study, 3 formulas were prepared with various base concentrations then tested for its antibacterial activity by disc diffusion method. On initial study showed that concentration of 30% angsana leaves extract gave best inhibition so it was used in formula. The base concentration at F1 was 0.4% carbopol 940 and 0.4% HPMC, F2, 0.2% carbopol 940 and 0.4% HPMC and F3, 0.4% carbopol at 10.5, 11mm, and 11mm. Combination gelling agent used in formula didn’t showed significance difference in antibacterial activities, but the formulas need further study to evaluated the performance.