Pharmacological Investigation on Unraveling Mechanism of Action of Qusqualis indica Leaves for Predicted Treatment of Peptic Ulcer Disease

Abstract

With the aid of various ulcer-induced models, the goal of this study was to assess the antiulcer ability of Qusqualis indica (Q. indica) leaf extracts in Wistar rats The induction of ulcers was done by different models like pylorus ligation method, ethanol-induced and stress-induced models. Group 1 (negative control), Group 2 (standard group) were treated with Sucralfate (8.6 mg/kg), Group 3 was treated with aqueous extract of Q. indica (AEQI,200 mg/kg), Group 4 was treated with aqueous extract of Q. indica (AEQI,400 mg/kg), Group 5 was treated with ethanolic extract of Q. indica (EEQI, 200 mg/kg) and Group 6 was treated with ethanol extract of Q. indica (EEQI, 400 mg/kg). All therapies were given orally twice every day. After the course of treatment was complete, blood and gastrointestinal contents were taken, and biochemical tests were run. The acetylcholine and histamine drug response curves were used to develop the mechanism of the extracts. The groups treated with extracts experienced a significant decrease in ulcer index. The antiulcer potential of the AEQI and EEQI is dose-dependent. Hematological, hepatic, and cardiac parameters were not significantly affected by the extracts, although high-density lipoprotein production was. Acetylcholine and histamine are blocked by AEQI and EEQI, according to the DRC analysis. The obtained scientific facts are amply supported by histopathological analysis AEQI and EEQI have antiulcer potential in a dose-dependent manner, but further research must be needed.