Interdigitated biosensor for D-serine detection, using gold nano-particles

Abstract

Analysis of biomarkers are of real importance because their excess or deficiency in body are at the base of diseases. Dserine is an aminoacid acting as a key regulator of NMDAR (NMethyl-D-aspartate-type glutamate receptor) activity. NMDAR have a central role in numerous significant procedures involving the nervous system, like synaptic plasticity, brain progress, and learning. The level of D-serine in the body is associated with various neuronal diseases. Development of novel affinity biosensors has quickly expanded and are among the most sensitive analytical devices available, offering low limits of detection and broad linear response ranges. In this work we report the design of gold interdigitated electrode overlaid on the silicon (Si) substrate using conventional photolithography process and tested to be applicable as a biosensor to detect the level of d-serine. Integrating microfluidics with biosensors is of great research interest with the increasing development of lab-on-the chip and point-of-care devices.