Does cerebral blood flow autoregulation differ between spontaneously increasing and decreasing sequences in blood pressure?

Abstract

The response of cerebral blood flow to increases and decreases in blood pressure have been reported to differ. The potential impact of this on the commonly used linear-time-invariant modelling of only spontaneous changes in blood pressure has so far not been tested. Results show that this could have a major impact on quantitative measures of cerebral autoregulaton.