Eliminación del virus de la hepatitis C en un centro penitenciario: una experiencia de 18 años

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Enfermedades infecciosas y microbiologia clinica Pub Date : 2024-05-01 DOI:10.1016/j.eimc.2023.01.002

Maite Nogales-Garcia , Naiara Parraza Diez , Andoni Vargas Axpe , Rafael Velasco Garcia , Ane Larrabeiti-Etxebarria , Ignacio Roy Lopez-Cano , Inmaculada Atrio Alvarez , Asier Lopez de Arcaute Trincado , Eva María Fernandez Lopez de Vicuña , Ester Saez de Adana Arroniz , Carlos Martínez Martínez , Joseba Portu Zapirain

{"title":"Eliminación del virus de la hepatitis C en un centro penitenciario: una experiencia de 18 años","authors":"Maite Nogales-Garcia , Naiara Parraza Diez , Andoni Vargas Axpe , Rafael Velasco Garcia , Ane Larrabeiti-Etxebarria , Ignacio Roy Lopez-Cano , Inmaculada Atrio Alvarez , Asier Lopez de Arcaute Trincado , Eva María Fernandez Lopez de Vicuña , Ester Saez de Adana Arroniz , Carlos Martínez Martínez , Joseba Portu Zapirain","doi":"10.1016/j.eimc.2023.01.002","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Despite the decrease of hepatitis C in Spanish prisons in the last years, it still remains a reservoir for infection. The aim of this work is to analyze the characteristics of these patients and the response to antiviral treatment over the last 18 years.</p></div><div><h3>Methods</h3><p>Retrospective observational study in inmates of Araba penitentiary center diagnosed with HCV infection between 2002 and 2020.</p><p>A descriptive analysis of patient characteristics and the response to the 3 antiviral treatment modalities was performed: peg-interferon and ribavirin, peg-interferon, ribavirin and a first-generation protease inhibitor and different combinations of direct-acting antivirals.</p></div><div><h3>Results</h3><p>A total of 248 antiviral treatments were prescribed. Treatment response rate up to 2015 was 65% and 93,7% after that year. Interferon non-responders were the main cause of non-response to treatment in periods 1 and 2 (40-50%). Conversely, in period 3 <em>viral breakthroug</em>h (67%) was the main culprit.</p></div><div><h3>Conclusion</h3><p>After 18 years, active hepatitis C infection in prison inmates has resolved with treatment according to clinical criteria. Therefore, the stay in prison may represent an opportunity to reduce the reservoir of the disease in the community, together with continued health care for those released from prison.</p></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":"42 5","pages":"Pages 236-241"},"PeriodicalIF":2.6000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Enfermedades infecciosas y microbiologia clinica","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0213005X23000162","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Despite the decrease of hepatitis C in Spanish prisons in the last years, it still remains a reservoir for infection. The aim of this work is to analyze the characteristics of these patients and the response to antiviral treatment over the last 18 years.

Methods

Retrospective observational study in inmates of Araba penitentiary center diagnosed with HCV infection between 2002 and 2020.

A descriptive analysis of patient characteristics and the response to the 3 antiviral treatment modalities was performed: peg-interferon and ribavirin, peg-interferon, ribavirin and a first-generation protease inhibitor and different combinations of direct-acting antivirals.

Results

A total of 248 antiviral treatments were prescribed. Treatment response rate up to 2015 was 65% and 93,7% after that year. Interferon non-responders were the main cause of non-response to treatment in periods 1 and 2 (40-50%). Conversely, in period 3 viral breakthrough (67%) was the main culprit.

Conclusion

After 18 years, active hepatitis C infection in prison inmates has resolved with treatment according to clinical criteria. Therefore, the stay in prison may represent an opportunity to reduce the reservoir of the disease in the community, together with continued health care for those released from prison.

查看原文本刊更多论文

在惩教机构消除丙型肝炎病毒：18 年的经验

导言尽管近年来西班牙监狱中丙型肝炎的发病率有所下降，但它仍然是一个传染源。本研究旨在分析这些患者的特征以及过去 18 年中对抗病毒治疗的反应。方法对 2002 年至 2020 年期间在阿拉巴监狱中心确诊感染 HCV 的囚犯进行回顾性观察研究。对患者特征和对三种抗病毒治疗方式的反应进行了描述性分析：聚干扰素和利巴韦林，聚干扰素、利巴韦林和第一代蛋白酶抑制剂，以及直接作用抗病毒药物的不同组合。2015年之前的治疗应答率为65%，2015年之后为93.7%。干扰素无效者是第一和第二阶段治疗无效的主要原因（40%-50%）。结论18 年后，根据临床标准，监狱囚犯中的活动性丙型肝炎感染经治疗后已得到缓解。因此，在狱中服刑可能是减少社区中丙型肝炎病毒库的一个机会，同时也是为刑满释放人员提供持续医疗保健的一个机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Enfermedades infecciosas y microbiologia clinica 医学-传染病学

CiteScore

2.10

自引率

8.00%

发文量

194

审稿时长

29 days

期刊介绍： Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.