R Janknegt, T Stratermans, J Cilissen, J J Lohman, P M Hooymans
{"title":"Ofloxacin intravenous. Compatibility with other antibacterial agents.","authors":"R Janknegt, T Stratermans, J Cilissen, J J Lohman, P M Hooymans","doi":"10.1007/BF01988876","DOIUrl":null,"url":null,"abstract":"<p><p>The physical and chemical compatibility of ofloxacin (infusion solution 100 ml = 200 mg) with amoxicillin, amoxicillin + clavulanic acid, flucloxacillin, tobramycin, gentamicin, clindamycin, vancomycin, ceftazidime and piperacillin was investigated. Upon admixture with flucloxacillin a precipitate formed between 7 and 24 hours. No other physical or chemical incompatibilities were observed with any of the other combinations. Ofloxacin may be safely combined with the tested antimicrobial drugs, except for flucloxacillin.</p>","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"13 5","pages":"207-9"},"PeriodicalIF":0.0000,"publicationDate":"1991-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01988876","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutisch weekblad. Scientific edition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF01988876","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The physical and chemical compatibility of ofloxacin (infusion solution 100 ml = 200 mg) with amoxicillin, amoxicillin + clavulanic acid, flucloxacillin, tobramycin, gentamicin, clindamycin, vancomycin, ceftazidime and piperacillin was investigated. Upon admixture with flucloxacillin a precipitate formed between 7 and 24 hours. No other physical or chemical incompatibilities were observed with any of the other combinations. Ofloxacin may be safely combined with the tested antimicrobial drugs, except for flucloxacillin.
考察氧氟沙星(输液液100 ml = 200 mg)与阿莫西林、阿莫西林+克拉维酸、氟氯西林、妥布霉素、庆大霉素、克林霉素、万古霉素、头孢他啶、哌拉西林的理化相容性。与氟氯西林混合后，在7至24小时内形成沉淀。没有观察到与任何其他组合的其他物理或化学不相容性。氧氟沙星可以安全地与除氟氯西林以外的抗微生物药物联合使用。
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