Disturbances in some plasma amino acids metabolomic profiles and their derivatives in Egyptian obese women

Abstract

Background: Obesity is a risk factor for several lifestyle diseases such as type II diabetes, hypertension, cancer and others. Studies have shown that plasma amino acids profile may be useful for screening lifestyle diseases. This case-control study aimed at investigating disturbances in acidic, basic, neutral, sulfur-containing amino acids besides imino amino acids profiles in Egyptian obese women to reach a healthy body and to stop any future complications of overweight. Methods: A total of 85 women were enrolled in this study that were classified into 5 groups (17 persons each):1-healthy, 2-overweights, 3-moderate obese, 4-severe obese, 5-morbid obese. Plasma metabolomic profile of the previous amino acids was evaluated using amino acid analyzer. Results: A statistically significant ascending increase in the mean plasma levels of citrulline, glutamate, proline and cysteine together with significant stepwise decrease in ornithine, serine, threonine, aspartate, histidine, arginine, methionine & taurine in obese subgroups as compared to controls. Conclusion: Our results of multivariate regression analysis demonstrated that the significantly elevated circulating lysine or proline levels were the best independent predictors for recognizing obese patients at risk of associated metabolic disorders and that the plasma AA metabolomic profile can be used as important biomarkers for early prediction of overweight women. Amino acids-directed regimens intervention could have significant impact on obesity management.