The Effects of Platelet-Rich Plasma on CTGF Produced by Fibroblasts in Hypertrophic Scars

Abstract

Hypertrophic scars are human dermal fibroproliferative disorder that occur following trauma, inflammation, surgery and burns. Connective Tissue Growth Factor (CTGF) is a cysteine-rich mitogen peptide that binds heparin and is secreted by fibroblasts after activation with Transforming Growth Factor beta (TGF ). Platelet-Rich Plasma (PRP) may serve as a source of different growth factors to induce fibrosis in hypertrophic scars.