Is HOMA-IR a potential screening test for non-alcoholic fatty liver disease in adults with type 2 diabetes?

Fayoum University Medical Journal Pub Date : 2019-12-01 DOI:10.21608/fumj.2019.66030

Remon Farag allah, M. Mashahit, A. Hamad, O. Zaki

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a major cause of liver related morbidity and mortality, because of its potential to progress to cirrhosis and liver failure. Patients with type 2 diabetes mellitus (T2DM) appear to have an increased risk of developing NAFLD. This study is a retrospective cohort study included 100 patients with type 2 DM from the outpatient clinic of internal medicine department at Fayoum University Hospital from (December, 2017 to June, 2018). They were divided into two equal groups according to the presence of NAFLD by ultrasound. All patients were subjected to history taking, clinical examination and investigations which included: ALT, AST, total cholesterol, TG, FBG and fasting insulin level. HOMA-IR was calculated by the following formula: HOMA-IR = [plasma glucose (mg/dL) × plasma insulin (μU/mL)] / 405. An association between HOMA-IR and NAFLD was found (OR: 1.25; 95% CI: 1.04 to 1.51; p = 0.020). A value of HOMA-IR of 4.2 was estimated to be an optimal threshold for discriminating NAFLD from nonNAFLD cases. ISSN: 2536-9474 (Print) Original article / FYMJ ISSN: 2536-9482 (Online) Fayoum University Medical Journal Farag allah et al., 2019,4(1), 21-29

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HOMA-IR是2型糖尿病成人非酒精性脂肪肝的潜在筛查试验吗?

非酒精性脂肪性肝病(NAFLD)越来越被认为是肝脏相关发病率和死亡率的主要原因，因为它有可能发展为肝硬化和肝功能衰竭。2型糖尿病(T2DM)患者发生NAFLD的风险增加。本研究为回顾性队列研究，纳入法尤姆大学附属医院内科门诊100例2型糖尿病患者(2017年12月- 2018年6月)。根据超声检查有无NAFLD分为两组。所有患者均进行病史、临床检查和调查，包括:ALT、AST、总胆固醇、TG、FBG、空腹胰岛素水平。HOMA-IR计算公式为:HOMA-IR =[血浆葡萄糖(mg/dL) ×血浆胰岛素(μU/mL)] / 405。发现HOMA-IR与NAFLD之间存在关联(OR: 1.25;95% CI: 1.04 ~ 1.51;P = 0.020)。估计HOMA-IR值为4.2是区分NAFLD和非NAFLD病例的最佳阈值。法尤姆大学医学杂志，2019,4(1)，21-29

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Fayoum University Medical Journal

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