In-vitro antibacterial activity of the fractions from Cleistocalyx operculatus (Roxb.) Merr. et Perry against Staphylococcus aureus

Journal of Science and Technology Issue on Information and Communications Technology Pub Date : 2023-06-30 DOI:10.31130/ud-jst.2023.056e

Van Ngo Thai Bich, Thao Dao Thi Thu, Thanh Hoa Tran, Phu Tran Vinh Phu

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Abstract

The prevalence of Gram-positive Staphylococcus aureus in infectious diseases is increasing in Vietnam for recent years. Therefore, novel class of antibiotic or active compounds is indispensable to treat this common worldwide pathogen. In the present study, we investigated the antibacterial activities of Cleistocalyx operculatus (Roxb.) Merr. et Perry leaves collected in Quang Nam. The results showed that ethanolic crude extract and three fractions partitioned in different polar solvents suppressed Staphylococcus aureus ATCC 6538. The ethyl acetate and n-hexan fractions exhibited a significant inhibitory effect, with minimum inhibitory concentrations (MIC) values of 0.1 mg/ml and 0.2 mg/ml, respectively. And flavonoids was possibly the active substances responsible for the antimicrobial activity of this medical plant. These initial findings are the premise of further studies for the treatment of infection. It also provides the scientific evidences for the traditional utilization of Cleistocalyx operculatus (Roxb.) Merr. et Perry leaves.

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闭锁花提取物的体外抗菌活性研究稳定。让佩里对抗金黄色葡萄球菌

近年来，越南革兰氏阳性金黄色葡萄球菌在传染病中的流行率呈上升趋势。因此，新型抗生素或活性化合物是治疗这一世界性常见病原体的必要条件。本研究主要研究了闭锁萼(Cleistocalyx operculatus)的抑菌活性。稳定。在广南收集的佩里树叶。结果表明，乙醇粗提物和不同极性溶剂分离的三组分对金黄色葡萄球菌ATCC 6538均有抑制作用。乙酸乙酯和正己烷组分表现出显著的抑菌效果，最低抑菌浓度(MIC)分别为0.1 mg/ml和0.2 mg/ml。黄酮类化合物可能是该药用植物抗菌活性的活性物质。这些初步发现是进一步研究感染治疗的前提。这也为闭锁花的传统利用提供了科学依据。稳定。让佩里离开。

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Journal of Science and Technology Issue on Information and Communications Technology

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