Fabrication and characterization of osteon mimetic microtubular scaffolds for bone tissue engineering application

Abstract

In the scope of bone tissue engineering, there has still been great amount of demand on designing biomimetic scaffolds that induces differentiation of osteoprogenitor cells by cell-matrix interaction at the nanoscale as well as mimicking micro assembly of compact bone while providing high mechanical strength. In this study, in order to use in the treatment of large bone defects, osteon mimetic 3D microtubular scaffolds were developed by using mineralized nanofiber sheets and characterized. The main goal for designing microtubular scaffolds is to mimic the nano and micro structures of bone tissue.