Computing in Ribosomes: Performing Boolean Logic Using mRNA-Ribosome System

Abstract

Continuous increase in bottlenecks with silicon-based conventional computers inspired researchers around the world to search for a non-conventional computing alternative that led to the development of DNA Computing, Quantum Computing etc. Each computing technologies came with their own advantages and disadvantages. Biology has inspired the computing through the pathway of DNA Computing. Since its inception it has been proven to be a powerful approach to solve computationally hard problems. But to solve otherwise general problems it needs mathematical ability. It lacks this ability in the sense that several manual interventions are required here. Moreover, the biomolecular operations in the DNA Labs are also slow to perform. To overcome this another molecule residing in the cell viz. ribosome can be used. Its automated procedure of translation can be used to perform the required operation. Recent development of artificial ribosome and the possibility of mutations in rRNAs residing in the ribosome has enabled the pathway of computation without any manual interventions. It can operate automatically at the speed of natural operations getting performed inside a living cell. This work has proposed a pathway to perform logic operations using the ribosomes.