Analysis of pathogenesis and treatment of endoplasmic reticulum stress in cardiovascular disease

Abstract

The pathogenesis and treatment of cardiovascular diseases are one of the key topics of current research. Existing studies have shown that endoplasmic reticulum stress has a non-negligible relationship with the occurrence and development of cardiovascular diseases. However, the pathogenesis and treatment of typical endoplasmic reticulum stress-induced cardiovascular diseases are still poorly understood. Therefore, this paper summarizes the pathogenesis and therapeutic drugs of some common cardiovascular diseases by sorting and analyzing the existing literature. Studies have found that excessive endoplasmic reticulum stress can cause serious damage to cells through the apoptosis pathway. Most of the treatment principles are to inhibit excessive endoplasmic reticulum stress by blocking signaling pathways, increasing or decreasing the expression of related genes, etc. The active components of a variety of Chinese herbal medicines are very effective in treating cardiovascular diseases caused by endoplasmic reticulum stress. Extracting the active components from plants or synthesizing new substances is an effective idea to find new therapies. The body response induced by endoplasmic reticulum stress can provide a reference for the study of other diseases with unknown pathogenesis.