Efficient mapping of DNA logic circuits on parallelized digital microfluidic architcture

Abstract

DNA is known as the basic element for storing the life codes and transferring the genetic features through the generations. However, it is found that DNA molecules can be utilized for a new kind of computation that opens fascinating horizons in computation and medical sciences. Significant contributions are addressed on design of DNA-based logic gates for medical and computational applications. Microfluidic biochips are known as efficient platforms to implement the DNA circuits but current biochips architectures allow sequential implementation of DNA modules that leads to increase the run time. In this paper, a new Microfluidic biochip architecture and corresponding CAD flow is presented for parallel implementation of DNA circuits. In this flow, Verilog description of the circuit files are synthesized and converted into a bioassay file format. Then assay files are implemented on a microfluidic biochip based on parallel architecture that mane is PBCM architecture. Experimental results show that the experimental time of assays and pin number of biochips are reduced by 17% and 23% respectively.