Optimised ladder-climbing rehabilitation training for various stroke severity levels in rats

IF 1 4区工程技术 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC

Iet Circuits Devices & Systems Pub Date : 2022-10-18 DOI:10.1049/cds2.12132

Chi-Chun Chen, Yu-Lin Wang, Ching-Ping Chang

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Abstract

To develop an optimised rehabilitation training system for various severity strokes in rats. The method provided feedback regarding the rat's measured position to a microprocessor, which adjusted the training speed accordingly and enables the rat to continuously exercise in the middle position of the ladder. This created a cyclic control system that provided various training intensities based on timely evaluations of the ladder-climbing capabilities of each rat, thus providing a suitable rehabilitation method for subjects with various stroke severities. The modified neurological severity score, rotarod and cerebral infarction volume results for the 60- and 90-min middle cerebral artery occlusion (MCAO) treadmill groups did not differ significantly from those of the control group. Conversely, the cerebral infarction volumes of the ladder-climbing rehabilitation groups in the 30-, 60-, and 90-min MCAO were all significantly lower than those of the control group (84.03 ± 23.24 vs. 256.77 ± 85.63 (mm³), 265.19 ± 41.12 versus 377.17 ± 90.97 (mm³), and 303.80 ± 47.15 versus 452.68 ± 90.44 (mm³) respectively), thereby indicating the optimised ladder-climbing method as effective for subjects with various stroke severities. Individual differences may cause different exercise capacities for each participant. To accommodate for these exercise capacities, an optimised ladder-climbing rehabilitation training system was proposed, which provided training according to the physical abilities of each participant.

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针对不同中风严重程度的大鼠，优化爬梯康复训练

针对不同严重程度的大鼠中风，开发一套优化的康复训练系统。该方法将测量到的大鼠位置反馈给微处理器，微处理器相应调整训练速度，使大鼠在梯子中间位置持续运动。这创造了一个循环控制系统，根据对每只大鼠爬梯能力的及时评估提供不同的训练强度，从而为不同中风严重程度的受试者提供合适的康复方法。60分钟和90分钟脑中动脉闭塞(MCAO)跑步机组的改良神经系统严重程度评分、rotarod和脑梗死体积结果与对照组无显著差异。相反，爬梯康复组在30min、60min和90min的脑梗死体积均显著低于对照组(分别为84.03±23.24 vs. 256.77±85.63 (mm3)、265.19±41.12 vs. 377.17±90.97 (mm3)、303.80±47.15 vs. 452.68±90.44 (mm3))，表明优化后的爬梯康复方法对不同脑卒中严重程度的受试者均有效。个体差异可能导致每个参与者的运动能力不同。为了适应这些运动能力，我们提出了一个优化的爬梯康复训练系统，根据每个参与者的身体能力提供训练。

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来源期刊

Iet Circuits Devices & Systems 工程技术-工程：电子与电气

CiteScore

3.80

自引率

7.70%

发文量

审稿时长

3 months

期刊介绍： IET Circuits, Devices & Systems covers the following topics: Circuit theory and design, circuit analysis and simulation, computer aided design Filters (analogue and switched capacitor) Circuit implementations, cells and architectures for integration including VLSI Testability, fault tolerant design, minimisation of circuits and CAD for VLSI Novel or improved electronic devices for both traditional and emerging technologies including nanoelectronics and MEMs Device and process characterisation, device parameter extraction schemes Mathematics of circuits and systems theory Test and measurement techniques involving electronic circuits, circuits for industrial applications, sensors and transducers