Eosinophilic Dermatosis of Hematological Malignancy Mimicking Wells Syndrome

Abstract

Wells syndrome, also known as eosinophilic cellulitis, is an inflammatory dermatitis that is often misdiagnosed as infectious cellulitis, leading to the inappropriate use of antibiotics and a delay appropriate treatment. We present a diagnostically challenging case where a 65-year-old male with a known case of SLL was found to have eosinophilic dermatosis of hematological malignancy after a thorough workup. Although the association between CLL and Wells syndrome is well established, we have not encountered any similar association or other cases of Wells syndrome associated with SLL in the literature. The pathophysiology underlying the association between eosinophilic cellulitis and CLL/SLL remains incompletely understood, and further investigation is warranted.