Versatile upconversion surfaces evaluation platform for bio-nano surface selection for nervous system

Abstract

Neurodegenerative disorder diseases have been perplexing physicians and scientists for many years. There is considerable interest in developing diagnostic nanotools for diagnosis and therapeutic treatment strategies for the neuron diseases. However, a key challenge remains in selection of suitable surface to overcome the nano-bio interface issue as many nanoparticles indicate instability when administered into biological environments and show serious cytotoxicity to sensitive central nervous system. We have developed new-generation upconversion nanoparticles (UCNPs) which represent a promising model nanoparticle for suitable evaluation due to its superior properties in bio photonics.