Influence of Brain Cooling on Frequency Characteristics of the Epileptic Focus and its Surrounding Area

Saya Kumano, Takashi Saito, Kenyu Uehara
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Abstract

In this study, we examined the suppression effect of brain cooling on the epileptic focus and surrounding area. An epileptic seizure was induced in rats to obtain electrocorticography (ECoG) data when brain cooling was performed on the epileptic focus and its surroundings. Then, the frequency response characteristics were calculated by applying fast Fourier transform (FFT) and band pass filter to the obtained multichannel brain wave data. At this time, the frequency band calculated by the band pass filter was α waves (8.0–13.0Hz) and β waves (13.0–30.0 Hz) which were remarkably observed in epileptic seizure in the previous study, the analysis window of FFT was 4.095 seconds, and the overlap was 75%. As a result of comparing the calculated frequency responses for each rat, it was found that at the site where epileptic seizures were observed, power was reduced by cooling and suppressing effect was observed, whereas at the same time, the power increased at the site a few millimeters adjacent to the seizure site. This result suggests that epileptic waves suppressed by brain cooling might propagate to the surrounding area by a few millimeters.
脑冷却对癫痫病灶及其周围区域频率特性的影响
在本研究中,我们观察了脑冷却对癫痫病灶和周围区域的抑制作用。当对癫痫病灶及其周围进行脑冷却时,诱导大鼠癫痫发作以获得脑皮质电图(ECoG)数据。然后,通过快速傅里叶变换(FFT)和带通滤波对得到的多通道脑电波数据进行频响特性计算。此时,通过带通滤波器计算的频带为α波(8.0 ~ 13.0Hz)和β波(13.0 ~ 30.0 Hz),这是前人研究中在癫痫发作中观察到的显著特征,FFT分析窗口为4.095秒,重叠率为75%。通过比较计算得到的每只大鼠的频率响应,发现在观察到癫痫发作的部位,通过冷却和抑制作用,功率降低,同时在癫痫发作部位附近几毫米处功率增加。这一结果表明,大脑降温抑制的癫痫波可能会向周围区域传播几毫米。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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