The Effects of High Fat High Carbohydrate (HFHC) Diet on Body Weight in Overweight Sprague Dawley Rats

Abstract

: Excessive body weight is caused by an inappropriate diet. Foods that are high in fat and carbohydrates may lead to overweight. When overweight condition is followed by an increase in the body fat level, it also increases the production of Reactive Oxygen Species (ROS) in the blood circulation and adipose cells. This study aims to determine the effect of High Fat High Carbohydrate (HFHC) diet on body weight of overweight Sprague dawley rats. This study used an experimental design with a pre-post-test control group design. Male Sprague dawley rats (n=10) were randomized into two groups. The normal group was given standard rats and the overweight group was given diet HFHC for 14 days. Their body weights were measured before and after treatment. After 14 days of treatment, the body weight mean was (210 ±1,5) in the treatment group increased significantly, compared with body weight mean (193±1,3) and before treatment (183,2±1,6) in the control group. In conclusion, those induced to be overweight used HFHC diet for 14 days and increased body weight. This finding can be used to induce overweight rats for a short time.