Evaluation of Trace Elements in Adult Sickle Cell Anaemia Patients in Zaria, North Western Nigeria

N. Garba, Ifeanyichukwu Om, Amilo Gi, I. Audu
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引用次数: 4

Abstract

Sickle cell anemia is a genetic disorder that is caused due to the inheritance of a mutant gene that encodes haemoglobin S (HbS). The amino acid glutamic acid is replaced with valine in the sixth position of b-globin chain. Protection of red cell membrane from free radical mediated oxidative stress is crucial to the management of SCD. Trace elements such as Copper, Zinc and Magnesium are of great benefit towards relieve of oxidative stress associated with red blood cell membranes. This study was carried out to evaluate some trace elements in adult sickle cell anaemia patientsattending sickle cell clinic, ABUTH-Zaria. Ethical clearance was obtained from ethics committee of Ahmadu Bello University Hospital Zaria, questionnaires were administered and informed consent was obtained from patients or their parents. One hundred and one (101) subjects aged 18 to 46 years participated in this study and these participants were divided into thirty five (35) confirmed sickle cell anaemia subjects in stable state (SS), thirty five (35) confirmed sickle cell anaemia subjects with history of vaso-occlusive crises in the last three months and (31) apparently healthy subjects (Hb AA) as control subjects (C). Haemoglobin electrophoresis was done using cellulose acetate method and serum copper, zinc and magnesium was analysed using Atomic Absorption Spectrophotometer (AAS) method. Serum copper, zinc and magnesium mean levels were significantly lower (P = 0.00) in SCA (SS and VOC) groups when compared with control group. No significance difference was observed in the mean levels of copper, zinc and magnesium in SS group when compared with VOC group (P = 0.36, P = 0.89 and P = 0.85) respectively. The mean levels of trace elements were significantly lower in SCA groups than the control group. Evaluation of trace elements is suggested in the management of sickle cell anaemia.
尼日利亚西北部扎里亚成年镰状细胞贫血患者微量元素的评价
镰状细胞性贫血是一种遗传性疾病,是由编码血红蛋白S (HbS)的突变基因遗传引起的。在b-珠蛋白链的第6位上用缬氨酸代替了氨基酸谷氨酸。保护红细胞膜免受自由基介导的氧化应激对SCD的治疗至关重要。微量元素,如铜、锌和镁,对缓解与红细胞膜有关的氧化应激有很大的好处。本研究旨在评估在阿布-扎里亚镰状细胞诊所就诊的成年镰状细胞贫血患者体内的一些微量元素。获得了Zaria Ahmadu Bello大学医院伦理委员会的伦理许可,进行了问卷调查,并获得了患者或其父母的知情同意。101名18 ~ 46岁的受试者被分为35名(35)稳定状态的确诊镰状细胞贫血(SS)、35名(35)最近3个月有血管闭塞危机史的确诊镰状细胞贫血(Hb AA)和31名(31)明显健康(Hb AA)作为对照(C)。用原子吸收分光光度法(AAS)对锌、镁进行了分析。SCA (SS和VOC)组血清铜、锌和镁的平均水平显著低于对照组(P = 0.00)。SS组的铜、锌、镁的平均含量与VOC组比较,差异均无统计学意义(P = 0.36, P = 0.89, P = 0.85)。SCA组的平均微量元素含量显著低于对照组。建议在镰状细胞性贫血的治疗中进行微量元素的评价。
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