Serum Interleukin 5 as an Indicator of Eosinophilic Esophagitis in Patients with ‎Chronic Upper GIT Symptoms‎ ‎ ‎

Abstract

in serum by ELISA was measured in all subjects. Results: By histopathological examination, six patients (7.5%) were diagnosed to have EoE. Endoscopic esophageal furrows, fissures/wrinkles; white exudate/granularity and concentric rings (trachealization) were significantly more frequent in patients with EoE than non EoE. Median concentration of serum IL-5 in EoE patients was 222.2pg/ml with range 187.5-307pg/ml while, it was 32.1pg/ml with range 15.6-113.6pg/ml in non EoE patients and 11.8pg/ml with range 13.4-38.2pg/ml in controls with P value < 0.001. ROC curve analysis showed that serum IL-5 can significantly predict EoE at a cut-off value of ≥103.2pg/ml with sensitivity 0.989 and = 0.96-1.0. Conclusion: Serum 5 could be an for eosinophilic esophagitis in patients with upper GIT However,