Portable Electrochemical Biosensors for Highly Sensitive Detection of Biomarkers

Abstract

The analysis of biomarkers plays an important role in the early diagnosis of diseases and will greatly benefit patients with a higher cure rate. However, the low abundance of biomarkers in physiological environments requires ultrahigh sensitivity of a detection technology.[1] Organic electrochemical transistors (OECT) are versatile sensing platform with low cost for easy-to-use, portable, and disposable biosensors. [2]-[4] They consist of gate electrode, source and drain electrodes with a thin layer of an organic semiconductor is deposited between them. [5]-[6] Here, we fabricate a portable and smart-phone-controlled biosensing platform based on disposable organic electrochemical transistors for ultrasensitive analysis of microRNA (miRNA) biomarkers within 1 hour.