EPTIDE THERAPY FOR EPILEPSY

Abstract

Goal: Investigate the role of cortexin in stopping and achieving remission of seizures in epilepsy. Material and methods: 47 patients with various forms of epilepsy were examined at the reception of a neurologist of the polyclinic department of the United City Hospital No. 7 during 2020-2021. To assess the psycho-emotional status, the Ziqmond scale was used. As a means of increasing stress resistance, cortexin was used. Statistical calculations of qualitative parameters were carried out using the Fisher criterion. The results are presented at the level of reliable significance p <0.05. Results and discussion: Psycho-emotional status, determined by the Ziqmond scale before treatment with cortexin, was rated low in all patients (6.91±0.13; m = 4, M = 11), and in female patients statistically significantly lower (8.05±0.32; m = 6, M = 13) than in male (8.83±0.21; m = 5, M = 12), (p = 0.046). During the study period (1 year), in 36 patients (31 cases from the group taking cortexin and 5 cases from the placebo group), seizures did not recur. The study proved a fairly high (83.78%) effectiveness of cortexin in improving the mental and emotional states of patients with epilepsy didn't repeat themselves. Conclusions: The inclusion of cortexin in the interictal period in the treatment regimen allows you to achieve a thymoleptic effect and prolong the remission of epileptic seizures. Keywords: polypeptide therapy, psycho-emotional status, cortexin, neuropeptides, epilepsy.