Low Dose Aspirin as Prophylaxis Reduces the Incidence of Preeclampsia in Women at High Risk – A Review

Abstract

Only pregnant women are susceptible to preeclampsia, a disorder that raises blood pressure and results in proteinuria, edema, or both. Although aspirin is not widely used due to safety and efficacy concerns, it is thought that high-risk pregnant women who take low doses of aspirin can avoid preeclampsia. Several clinical studies are been out on high-risk female patients to prevent preeclampsia with low dose aspirin (60-150 mg). Using a combination of keywords, the literature database that is available on multiple peer-reviewed national and international journals was searched electronically. Between 8 and 28 weeks of gestation, aspirin 100 mg or 150 mg was given together with a placebo to high-risk pregnant women in 11 RCTs. According to the existing research, preeclampsia and its associated foetal and maternal problems can be prevented or when high-risk pregnant women are given low-dose aspirin between 12 and 28 weeks of gestation, especially at night, the risk is decreased.