Cellulose Nanocrystals as a Versatile Platform for Regulation of Myeloid Cell Immunogenicity

Proceedings of the 7th World Congress on Recent Advances in Nanotechnology Pub Date : 2022-04-01 DOI:10.11159/nddte22.149

S. Tomić, M. Bekić, M. Vasiljević, D. Stojanović, D. Vučević, P. Uskoković, M. Čolić, V. Kokol

引用次数: 0

Abstract

Extended Abstract Phosphonates possess a great potential for the therapy of bone tumours due to their inhibitory potential for osteoclasts. The delivery of phosphonates via cellulose nanocrystals (CNCs) seems a promising approach for their increased efficacy in target tissues. However, the immunological effects of these conjugates have not been investigated thoroughly. Here we modified used wood-based native (n)CNC, oxidized (ox-CNC) and phosphonate (3-AminoPropylphosphonic Acid (ApA))-conjugated CNC to test their physicochemical properties and immunomodulatory potential. Modification of CNC increased their elasticity module and hardness, which resulted in their reduced internalization by

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纤维素纳米晶体作为髓细胞免疫原性调控的通用平台

膦酸盐具有抑制破骨细胞的潜力，因此在骨肿瘤的治疗中具有很大的潜力。通过纤维素纳米晶体(CNCs)递送膦酸盐似乎是一种很有前途的方法，因为它们在靶组织中具有更高的功效。然而，这些缀合物的免疫学作用尚未得到充分的研究。在此，我们对使用过的木质天然CNC、氧化CNC和膦酸(3-氨基丙基膦酸(ApA))共轭CNC进行了改性，测试了它们的理化性质和免疫调节潜能。CNC的修改增加了它们的弹性模块和硬度，导致它们的内在化程度降低

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Proceedings of the 7th World Congress on Recent Advances in Nanotechnology

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