Current mechanisms in the pathogenesis of lung fibrosis

M. Engin, Ö. Özdemir
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引用次数: 1

Abstract

Pulmonary fibrosis is a diverse group of lung disorders defined by varying degrees of fibrosis and inflammation in the pulmonary parenchyma. While it may be caused by a known disease, e.g., autoimmune or connective tissue disorder, drugs, hypersensitivity to inhaled organic antigens, or sarcoidosis, it also occurs to be idiopathic. When we examine the pathogenesis of lung fibrosis, we see that cellular aging plays a major role. Lung fibroblasts play an active role in the regeneration process. However, despite all the information, the pathogenesis of lung fibrosis is not clearly understood. It is not yet clear how senescent cells in the lung mingle and cause fibrosis. The pathogenesis of lung fibrosis will be understood more clearly following future studies.
当前肺纤维化的发病机制
肺纤维化是一组不同程度的肺实质纤维化和炎症所定义的肺部疾病。虽然它可能是由一种已知的疾病引起的,例如,自身免疫或结缔组织疾病、药物、对吸入的有机抗原过敏或结节病,但它也可能是特发性的。当我们研究肺纤维化的发病机制时,我们发现细胞衰老起着主要作用。肺成纤维细胞在再生过程中发挥积极作用。然而,尽管有这些信息,肺纤维化的发病机制尚不清楚。目前尚不清楚肺部衰老细胞是如何混合并引起纤维化的。肺纤维化的发病机制将在今后的研究中进一步明确。
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