Computer-assisted Inductive Moderate Hyperthermia Planning For Breast Cancer Patients

2020 IEEE 40th International Conference on Electronics and Nanotechnology (ELNANO) Pub Date : 2020-04-01 DOI:10.1109/ELNANO50318.2020.9088908

V. Orel, Oleksdandr Rykhalskyi, L. Syvak, I. Smolanka, A. Loboda, A. Lyashenko, I. Dosenko, A. Mokhonko, T. Golovko, A. Ganich, V. B. Orel

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引用次数: 4

Abstract

This paper demonstrates the basic principles of personalized computer-assisted regional inductive moderate hyperthermia (RIMH) planning for locally advanced breast cancer and treatment outcomes of stage IIB-IIIA patients. COMSOL Multiphysics 5.4 was used to modulate the distribution of the electromagnetic and temperature fields in the tumor during RIMH based on magnetic resonance imaging scans. Patients were divided into 2 groups. The control group received 4 courses of FAC (5-fluorouracil, doxorubicin, cyclophosphamide) neoadjuvant chemotherapy, while the main group received a 30-minute RIMH session at a frequency of 27.12 MHz and an output power of 50 W delivered by MagTherm (Radmir, Kharkiv, Ukraine) after each neoadjuvant chemotherapy administration. RIMH in combination with neoadjuvant chemotherapy significantly improved tumor response by 15.9% (p = 0.034) and the 5-year overall survival by 14.6% (p = 0.024).

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乳腺癌患者的计算机辅助诱导适度热疗计划

本文阐述了针对局部晚期乳腺癌的个性化计算机辅助局部诱导适度热疗(RIMH)计划的基本原则和IIB-IIIA期患者的治疗结果。基于磁共振成像扫描，使用COMSOL Multiphysics 5.4调制RIMH期间肿瘤内的电磁场和温度场分布。患者分为两组。对照组接受4个疗程的FAC(5-氟尿嘧啶、阿霉素、环磷酰胺)新辅助化疗，而主组每次新辅助化疗后，由MagTherm (Radmir, Kharkiv, Ukraine)提供频率为27.12 MHz、输出功率为50 W的RIMH疗程30分钟。RIMH联合新辅助化疗可显著提高肿瘤应答率15.9% (p = 0.034)， 5年总生存率14.6% (p = 0.024)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2020 IEEE 40th International Conference on Electronics and Nanotechnology (ELNANO)

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