Autoimmune necrotizing myositis. Presentation of a clinical case

Sabrina Plou, María Elena Gaona, V. Caputo
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Abstract

Inflammatory myopathies (IM) or myositis are a heterogeneous group of muscle diseases of rare occurrence. Such diseases are characterized by inflammation of the different components of muscle tissue, which can occur either in isolation or, more commonly, as part of a systemic disorder. Immune-mediated necrotizing myopathies (IMNM) are a type of autoimmune myopathy characterized by proximal muscle weakness, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy and infrequent extramuscular involvement. Even though there are clinical and histopathological similarities. The spectrum of inflammatory myopathies is considerably variable. Therefore, the performance of complementary studies is essential for the proper identification of the IM subtype to contribute accurately on treatment so determine the better prognosis). The present article shows the case of a young 29 years old, with no personal and family history background of autoimmune disease and no relevant pathological back-ground. The patient consulted the medical ward of the Institution with pain, functional impairment of upper and lower extremities, muscle weakness mainly located in the pectoral girdle area and, although to a lesser degree, in the pelvic girdle area. It was also associated with asthenia, tendency to drowsiness and hyporeactivity.
自身免疫性坏死性肌炎。报告一个临床病例
炎症性肌病(IM)或肌炎是一种罕见的异质性肌肉疾病。这类疾病的特点是肌肉组织的不同组成部分发生炎症,既可以单独发生,也可以更常见地作为全身性疾病的一部分发生。免疫介导的坏死性肌病(IMNM)是一种自身免疫性肌病,其特征是近端肌肉无力,肌纤维坏死,肌肉活检显示有少量炎症细胞浸润,很少累及肌外。尽管有临床和组织病理学上的相似之处。炎症性肌病的频谱变化很大。因此,补充研究的表现对于正确识别IM亚型以准确地帮助治疗以确定更好的预后至关重要)。本文报告一例29岁的年轻患者,无自身免疫性疾病的个人和家族史背景,也无相关的病理背景。该患者因疼痛、上肢和下肢功能障碍、肌肉无力(主要位于胸带区,尽管程度较轻)到该机构的病房就诊。它还与身体虚弱、嗜睡和反应迟钝有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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