ASSESSING THE EFFECTIVENESS OF PROANECY HEPA MILK FOR PREVENTING AN INCREASE OF BLOOD ETHANOL CONCENTRATION

Abstract

Aims: This study aimed to investigate whether consuming 6ml/kg of Proanecy Hepa milk prior to alcohol consumption could limit the increase in blood alcohol concentration (BAC). Methods: A self-controlled clinical trial with 6 ethanol pharmacokinetic crossover trials was performed. Ten fasting students were divided into six groups, each receiving different substances before consuming 0.5g of ethanol/kg. The substances administered included Pure water, Alcohol antidote, Proanecy Hepa milk, Proanecy Hepa milk without Silymarin, Silymarin, and Liver support milk. BAC was measured at five-time points using gas chromatography: baseline (t0), 60 minutes (t1), 120 minutes (t2), 180 minutes (t3), and 240 minutes (t4) after alcohol intake. iAUC of blood ethanol were presented as median (interquartile range). Results: The group that consumed Proanecy Hepa demonstrated a significantly lower increase in BAC, as indicated by the incremental area under the curve (iAUC) (170.9,  50.5-470.8), compared to the other groups (p< 0.001). The median iAUC for the remaining groups were as follows: pure water 2885.1 (2405.7-3005.3), alcohol antidote 2973.9 (2744.2-3369.5), Proanecy Hepa without Silymarin 2295.9 (1222.5-2569.4), Silymarin 3411.8 (3006.2-3922), and Liver support milk 2739.4 (2431.8-3149.4). Furthermore, individuals who consumed 6ml/kg of Proanecy Hepa before alcohol intake maintained BAC below the positive threshold of 10 mg/dl at all measured time points (60, 120, 180, and 240 minutes). In contrast, individuals in the control groups exceeded the positive threshold at those time points except for minute 240. Conclusions: The study suggests that consuming 6 ml/kg of Proanecy Hepa milk 30 minutes before consuming 0.5g of ethanol/kg can help prevent blood alcohol levels from exceeding the positive threshold of 10 mg/dl.