The relationship between vitamin D deficiency and diabetes Type 1,2: a review

Abstract

Types 1 and 2 diabetes are predisposed to people with vitamin D deficiency, and immune cells and beta cells were found to include receptors for vitamin D’s activated form, 1 α, 25-dihydroxyvitamin D3. Type II diabetes was linked to vitamin D deficiency, which was proven to affect insulin synthesis and secretion in people and diabetes-prone animals. In addition, epidemiological research suggests a connection of the deficiency of vitamin D in adolescence with type I diabetes onset later in life. Various polymorphisms in vitamin D receptor genes have been linked to type I diabetes in certain groups. Pharmacological dosages of 1 α, 25-di-hydroxyvitamin D3, or its structural counterparts were proven in tests on nonobese diabetic mice to postpone the onset of diabetes, mostly by modulating the immune system. Thus, vitamin D deficiency could have an influence upon etiology of both types of diabetes, and a deeper comprehension of the underlying mechanisms might help create preventative measures.