Outcomes of Entropion Repair in Ocular Cicatricial Pemphigoid Compared to Other Cicatricial Etiologies: A Retrospective Study

Abstract

Background: Ocular cicatricial pemphigoid (OCP) can lead to severe conjunctival scarring and cicatricial entropion, which often necessitates repair. Surgical manipulation can increase the risk of inflammation, scarring, and disease progression. The objective of this study was to understand the characteristics of OCP patients who received entropion repairs and determine the difference in entropion recurrence or revision in patients with OCP or other cicatricial entropion repair. Methods: A retrospective chart review was performed from January 2010 to June 2020. OCP patients from an autoimmune blistering disease clinic with entropion repair were compared to patients with repair of cicatricial entropion of other etiology. A generalized estimating equation assessed for evidence of recurrence of entropion or required revision. Results: 19 OCP patients with cicatricial entropion and 60 patients with cicatricial entropion secondary to other etiologies received 38 and 75 entropion repairs, respectively. No difference in prevalence of revision or recurrence was found between groups. Conclusion: This study provides evidence that in a population of OCP patients where the majority were systemically immunosuppressed, the likelihood of entropion recurrence or further repair was no different than that for repair of cicatricial entropion of other etiology.