Correlation between serum uric acid and renal function in diabetes with normalbuminuria

Abstract

Background: Diabetes mellitus (DM) is one of the most prevalent health issues worldwide. The present study was conducted to assess correlation between serum uric acid and renal function in diabetes with normalbuminuria. Materials & Methods: The present study was conducted on 256 diabetic patients of both genders. The level of urinary creatinine was assayed using the same method as that for serum creatinine. Evaluation of GFR (eGFR) was done according to the CKD-EPI formula. Results: out of 256 patients, males were 146 and females were 110. Out of 146 males, 30 males and out of 110 females, 22 females had hyperuricemia. The mean BMI (kg/m2) in group I was 24.1, in group II was 24.3, in group III was 25.1 and group IV was 25.4. Mena FBG (mmol/L) in group I was 8.6, in group II was 7.5, in group III was 7.4 and in group IV was 7.1, Mean urine pH was 5.9 in group I, 5.7 in group II, 5.6 in group III and 5.1 in group IV, Mean UACR in group I was 10.8 in group I, 9.02 in group II, 9.08 in group III and 10.2 in group IV. Mean eGFR (ml/min/1.73m 2 ) in group I was 89.2, in group II was 85.3, in group III was 82.5 and in group IV was 79.4. The difference was significant (P< 0.05). A correlation of FBG (mmol/L), urine pH, SUA (µmol/L) and UACR with eGFR was found. Conclusion: Authors suggested that hyperuricemia should be controlled efficiently to prevent the GFR decrease and protect the renal function in these patients.