Analogue Realization of Fractional-Order Healthy and Cancerous Lung Cell Models for Electrical Impedance Spectroscopy

Abstract

This work proposes an integrated-circuit architecture emulating healthy and cancerous lung cell behaviors, approximated by Cole models and is suitable for calibration and phantom experimental testing of electrical bioimpedance circuits and systems. The architecture is based on fractional-order elements implemented with both active and passive components, offering an accurate transfer function behavior between 10kHz and 1MHz. The high-level architecture includes an analog all-pass filter coupled with a current conveyor. Performance and accuracy of the proposed architecture is confirmed via Monte-Carlo simulation. The proposed circuitry has been designed in TSMC 90nm CMOS process and simulated using the Cadence IC suite.