Computed aided system for separation and classification of the abnormal erythrocytes in human blood

M. Wąsowicz, M. Grochowski, M. Kulka, Agnieszka Mikołajczyk, M. Ficek, K. Karpienko, M. Cićkiewicz
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引用次数: 9

Abstract

The human peripheral blood consists of cells (red cells, white cells, and platelets) suspended in plasma. In the following research the team assessed an influence of nanodiamond particles on blood elements over various periods of time. The material used in the study consisted of samples taken from ten healthy humans of various age, different blood types and both sexes. The markings were leaded by adding to the blood unmodified diamonds and oxidation modified. The blood was put under an impact of two diamond concentrations: 20μl and 100μl. The amount of abnormal cells increased with time. The percentage of echinocytes as a result of interaction with nanodiamonds in various time intervals for individual specimens was scarce. The impact of the two diamond types had no clinical importance on red blood cells. It is supposed that as a result of longlasting exposure a dehydratation of red cells takes place, because of the function of the cells. The analysis of an influence of nanodiamond particles on blood elements was supported by computer system designed for automatic counting and classification of the Red Blood Cells (RBC). The system utilizes advanced image processing methods for RBCs separation and counting and Eigenfaces method coupled with the neural networks for RBCs classification into normal and abnormal cells purposes.
人血液中异常红细胞分离与分类的计算机辅助系统
人的外周血由悬浮在血浆中的细胞(红细胞、白细胞和血小板)组成。在接下来的研究中,研究小组评估了纳米金刚石颗粒在不同时期对血液元素的影响。研究中使用的材料包括从10个不同年龄、不同血型和两性的健康人身上采集的样本。这些标记是通过在血液中加入未经修饰的钻石和氧化修饰的钻石来确定的。血液受到20μl和100μl两种金刚石浓度的影响。异常细胞数量随时间增加而增加。在不同的时间间隔内,单个标本中由于与纳米金刚石相互作用而产生的棘细胞百分比很少。两种钻石类型对红细胞的影响没有临床意义。据推测,由于长时间的暴露,由于细胞的功能,红细胞会发生脱水。纳米金刚石颗粒对血液元素的影响分析是由设计用于红细胞自动计数和分类的计算机系统支持的。该系统利用先进的图像处理方法进行红细胞分离和计数,并结合神经网络将红细胞分为正常和异常细胞。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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