Electrospun bioresorbable tissue repair scaffolds: From laboratory to clinic

Abstract

The healing of soft tissue wounds and injury sites is a complex process requiring the participation of many different cells, tissues, proteins and tissue components in a coordinated manner. We describe the development of regenerative, electrospun, bioresorbable advanced material tissue scaffolds providing three dimensional (3D) structure for cells involved in the repair of soft tissue injuries. One product, EktoTherix™ provides a micron-scale 3D architecture to enhance the recruitment of reparative cells onto this temporary support and in this way the body's capacity to repair itself is utilised. EktoTherix and other electrospun tissue scaffolds have been translated from early stage laboratory work through manufacturing process development and clinical investigation.