EXOSOME’ EMERGING FUNCTION IN CARCINOGENESIS AND CANCER CHEMOTHERAPY RESISTANCE

Era's Journal of Medical Research Pub Date : 2023-06-01 DOI:10.24041/ejmr2023.18

Raushan Kumar, Sharique Ahmad

{"title":"EXOSOME’ EMERGING FUNCTION IN CARCINOGENESIS AND CANCER CHEMOTHERAPY RESISTANCE","authors":"Raushan Kumar, Sharique Ahmad","doi":"10.24041/ejmr2023.18","DOIUrl":null,"url":null,"abstract":"Globally, cancer and related disorders are major health issues. The scientific community has many obstacles in tackling this problem and creating a streamlined therapy and drug administration plan. Chemotherapy is necessary for cancer treatment, however many individuals acquire drug resistance due to recurrent medication delivery. Chemotherapy resistance hinders cancer treatment. Exosomes are vesicles their size range from 40 to 160 nm (the average being 100 nm). Exosomes can include DNA, RNA, fatty acid, metabolites as well cytosol, and cell surface proteins. Since exosome formation's physiological purpose is unknown, more research is needed. Exosomes regulate intercellular communication and help cancer cells develop chemoresistance. Exosomes can reveal physiological and pathological information about their parent cells. Liquid biopsies assess cancer chemosensitivity using exosomes. Because exosomes are stable and sensitive. This review covers exosome-mediated cancer chemoresistance. We also studied tumor-related processes, exosome biogenesis, and their current and potential roles in cancer diagnosis and treatment, drug delivery systems, and chemoresistance.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"100 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Era's Journal of Medical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24041/ejmr2023.18","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Globally, cancer and related disorders are major health issues. The scientific community has many obstacles in tackling this problem and creating a streamlined therapy and drug administration plan. Chemotherapy is necessary for cancer treatment, however many individuals acquire drug resistance due to recurrent medication delivery. Chemotherapy resistance hinders cancer treatment. Exosomes are vesicles their size range from 40 to 160 nm (the average being 100 nm). Exosomes can include DNA, RNA, fatty acid, metabolites as well cytosol, and cell surface proteins. Since exosome formation's physiological purpose is unknown, more research is needed. Exosomes regulate intercellular communication and help cancer cells develop chemoresistance. Exosomes can reveal physiological and pathological information about their parent cells. Liquid biopsies assess cancer chemosensitivity using exosomes. Because exosomes are stable and sensitive. This review covers exosome-mediated cancer chemoresistance. We also studied tumor-related processes, exosome biogenesis, and their current and potential roles in cancer diagnosis and treatment, drug delivery systems, and chemoresistance.

查看原文本刊更多论文

外泌体在癌症发生和癌症化疗耐药中的新功能

在全球范围内，癌症和相关疾病是主要的健康问题。科学界在解决这个问题和制定一个精简的治疗和药物管理计划方面存在许多障碍。化疗对于癌症治疗是必要的，然而许多个体由于反复给药而产生耐药性。化疗耐药性阻碍了癌症的治疗。外泌体是囊泡，大小从40到160纳米不等(平均为100纳米)。外泌体可以包括DNA、RNA、脂肪酸、代谢物以及细胞质和细胞表面蛋白。由于外泌体形成的生理目的尚不清楚，需要更多的研究。外泌体调节细胞间通讯并帮助癌细胞产生化学耐药性。外泌体可以揭示其亲本细胞的生理和病理信息。液体活检使用外泌体评估癌症的化学敏感性。因为外泌体稳定而敏感。本文综述了外泌体介导的癌症化学耐药。我们还研究了肿瘤相关过程、外泌体生物发生及其在癌症诊断和治疗、药物输送系统和化疗耐药中的当前和潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Era's Journal of Medical Research

自引率

0.00%

发文量