Chapter 8. Multidimensional LC-GC

M. Biedermann, K. Grob
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Abstract

Using liquid chromatography (LC; often high-resolution liquid chromatography, HPLC) for sample clean-up and pre-separation seems an obvious way to improve analyses through greatly enhanced selectivity, lower detection limits, automation, reduced solvent consumption and improved quantitative results. The basic technology was developed between 1980 and 2000, but has been more widely applied in a routine manner only since about 2010, triggered by mineral oil analysis in food. Pre-separation liquid chromatography and the use of detectors for accurately determining the relevant fraction are well-established technologies, fast and more efficient than alternative methods. It was the transfer of large volumes of liquid to gas chromatography (GC), usually based on solvent effects and the retention gap technique, that challenged analysts. Particularly in the 1990s, numerous ideas, techniques and methods have been described, highlighting the potential, but so far little has become routine. This review deals with mainstream online LC-GC, but also with ideas considered interesting and perhaps worthwhile to follow up in further developments.
第八章。多维LC-GC
采用液相色谱法(LC;通常高分辨率液相色谱法(HPLC)用于样品清理和前分离似乎是一种明显的方法,通过大大提高选择性,降低检测限,自动化,减少溶剂消耗和改善定量结果来改善分析。这项基础技术是在1980年至2000年间发展起来的,但直到2010年左右,由于食品中的矿物油分析,才开始以常规方式得到更广泛的应用。分离前液相色谱法和使用检测器准确测定相关组分是成熟的技术,比其他方法更快、更有效。将大量液体转移到气相色谱(GC),通常是基于溶剂效应和保留间隙技术,这对分析人员来说是一个挑战。特别是在20世纪90年代,已经描述了许多想法,技术和方法,突出了潜力,但到目前为止,很少成为常规。这篇综述涉及主流的在线LC-GC,但也有一些想法被认为是有趣的,也许值得在进一步的发展中跟进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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