Predicting cirrhosis based on standard laboratory parameters in patients with chronic hepatitis C virus infection

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI:10.2298/JMB0603255S

N. Svirtlih, D. Delić, Jasmina Simonović-Babić, N. Maksić, E. Gvozdenović, L. Dokić, I. Boricic, S. Pavić, Dragica Draskovic, Z. Nešić

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Abstract

Total of 153 patients with chronic Hepatitis C Virus infection was investigated. Patients were classified into three groups: with histologic confirmed liver cirrhosis, clinical advanced cirrhosis, and chronic hepatitis without fibrosis. Activity of aminotransferases (AST, ALT), value of INR and platelet counts were analyzed by SPSS for Windows (version 10.0). Probability of cirrhosis was calculated by HALT-C formula and expressed in percent (http://www.haltctrial.org). Thrombocytopenia was the most important predictive factor for progression/exclusion of cirrhosis. Probability of cirrhosis in patients with histologic cirrhosis, clinical cirrhosis and chronic hepatitis without fibrosis was from 23-93%, 41-98% and 4-65%, respectively. Probability equal/more than 50% had 60%, 90% and 14% of patients from the same groups. In conclusion, liver cirrhosis can be predicted based on standard laboratory parameters in more than half of patients with chronic hepatitis C virus infection. .

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基于标准实验室参数预测慢性丙型肝炎病毒感染患者的肝硬化

对153例慢性丙型肝炎病毒感染患者进行了调查。患者分为三组:组织学证实的肝硬化，临床晚期肝硬化和无纤维化的慢性肝炎。采用SPSS for Windows (version 10.0)软件分析转氨酶(AST、ALT)活性、INR值和血小板计数。根据HALT-C公式计算肝硬化概率，以百分比表示(http://www.haltctrial.org)。血小板减少是肝硬化进展/排除最重要的预测因素。组织学肝硬化、临床肝硬化和无纤维化慢性肝炎患者发生肝硬化的概率分别为23-93%、41-98%和4-65%。概率等于/大于50%的患者分别有60%、90%和14%来自同一组。总之，半数以上的慢性丙型肝炎病毒感染患者可根据标准实验室参数预测肝硬化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry

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