Dietary nicotine intake and risk of Parkinson disease: a prospective study.

The American journal of clinical nutrition Pub Date : 2020-05-29 DOI:10.1093/cdn/nzaa057_038

Chaoran Ma, Samantha A. Molsberry, Yanping Li, M. Schwarzschild, A. Ascherio, Xiang Gao

{"title":"Dietary nicotine intake and risk of Parkinson disease: a prospective study.","authors":"Chaoran Ma, Samantha A. Molsberry, Yanping Li, M. Schwarzschild, A. Ascherio, Xiang Gao","doi":"10.1093/cdn/nzaa057_038","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nTobacco use was observed to be associated with a lower risk of Parkinson disease (PD) in previous epidemiologic studies, with nicotine as a potential candidate. The association between dietary nicotine and PD risk has, however, not been examined in prospective studies yet.\n\n\nOBJECTIVES\nWe aimed to examine prospectively the association between dietary nicotine intake and subsequent PD risk among never-smokers.\n\n\nMETHODS\nThe current study was based on never-smoker participants from 2 large prospective cohorts: the Nurses' Health Study (n = 31,615) and the Health Professionals Follow-up Study (n = 19,523). The studies contained information on dietary nicotine intake from 1986 from validated FFQs. Dietary nicotine intake was calculated based on consumption of peppers, tomatoes, processed tomatoes, potatoes, and tea. Incident cases of PD were identified via questionnaires and subsequently confirmed by reviewing medical records. We used Cox proportional hazard models to calculate cohort-specific HRs, and used fixed-effects models to calculate the pooled HR.\n\n\nRESULTS\nDuring 26 y of follow-up, we identified 601 incident PD cases (296 women and 305 men). After adjusting for potential covariates, the pooled HR for the highest compared with the lowest quintile of dietary nicotine intake was 0.70 (95% CI: 0.51, 0.94). The significant inverse association was, however, only observed in women (adjusted HR: 0.64; 95% CI: 0.42, 0.96), not in men (adjusted HR: 0.77; 95% CI: 0.50, 1.20). Further adjusting for environmental tobacco smoke exposure, family history of PD, and use of ibuprofen generated similar significant results in women. Consistently, greater consumption of peppers was associated with lower risk of PD (adjusted HR for ≥5 times/wk compared with ≤3 times/mo: 0.49; 95% CI: 0.25, 0.94) in women but not in men (adjusted HR: 1.04; 95% CI: 0.57, 1.90).\n\n\nCONCLUSIONS\nWomen with greater dietary nicotine intake had a lower risk of PD than those with lower intake.","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"46 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The American journal of clinical nutrition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/cdn/nzaa057_038","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 9

Abstract

BACKGROUND Tobacco use was observed to be associated with a lower risk of Parkinson disease (PD) in previous epidemiologic studies, with nicotine as a potential candidate. The association between dietary nicotine and PD risk has, however, not been examined in prospective studies yet. OBJECTIVES We aimed to examine prospectively the association between dietary nicotine intake and subsequent PD risk among never-smokers. METHODS The current study was based on never-smoker participants from 2 large prospective cohorts: the Nurses' Health Study (n = 31,615) and the Health Professionals Follow-up Study (n = 19,523). The studies contained information on dietary nicotine intake from 1986 from validated FFQs. Dietary nicotine intake was calculated based on consumption of peppers, tomatoes, processed tomatoes, potatoes, and tea. Incident cases of PD were identified via questionnaires and subsequently confirmed by reviewing medical records. We used Cox proportional hazard models to calculate cohort-specific HRs, and used fixed-effects models to calculate the pooled HR. RESULTS During 26 y of follow-up, we identified 601 incident PD cases (296 women and 305 men). After adjusting for potential covariates, the pooled HR for the highest compared with the lowest quintile of dietary nicotine intake was 0.70 (95% CI: 0.51, 0.94). The significant inverse association was, however, only observed in women (adjusted HR: 0.64; 95% CI: 0.42, 0.96), not in men (adjusted HR: 0.77; 95% CI: 0.50, 1.20). Further adjusting for environmental tobacco smoke exposure, family history of PD, and use of ibuprofen generated similar significant results in women. Consistently, greater consumption of peppers was associated with lower risk of PD (adjusted HR for ≥5 times/wk compared with ≤3 times/mo: 0.49; 95% CI: 0.25, 0.94) in women but not in men (adjusted HR: 1.04; 95% CI: 0.57, 1.90). CONCLUSIONS Women with greater dietary nicotine intake had a lower risk of PD than those with lower intake.

查看原文本刊更多论文

饮食尼古丁摄入与帕金森病风险:一项前瞻性研究

背景在之前的流行病学研究中发现吸烟与帕金森病(PD)的低风险相关，尼古丁是一个潜在的候选者。然而，膳食尼古丁与帕金森病风险之间的关系尚未在前瞻性研究中得到检验。目的:我们旨在前瞻性地研究不吸烟者饮食尼古丁摄入量与随后PD风险之间的关系。方法目前的研究基于来自两个大型前瞻性队列的从不吸烟参与者:护士健康研究(n = 31,615)和卫生专业人员随访研究(n = 19,523)。这些研究包含了1986年以来膳食尼古丁摄入量的信息，这些信息来自经过验证的FFQs。饮食中尼古丁的摄入量是根据辣椒、番茄、加工番茄、土豆和茶的摄入量来计算的。通过问卷调查确定PD的偶发病例，随后通过查阅医疗记录进行确认。我们使用Cox比例风险模型来计算队列特定的HR，并使用固定效应模型来计算合并HR。结果在26年的随访中，我们确定了601例PD病例(女性296例，男性305例)。在对潜在协变量进行调整后，饮食尼古丁摄入量最高与最低五分位数的合并HR为0.70 (95% CI: 0.51, 0.94)。然而，显著的负相关仅在女性中观察到(调整后的HR: 0.64;95% CI: 0.42, 0.96)，男性没有(调整后HR: 0.77;95% ci: 0.50, 1.20)。进一步调整环境烟草烟雾暴露、PD家族史和布洛芬的使用在女性中也产生了类似的显著结果。一致地，更多的辣椒消费与较低的PD风险相关(调整HR≥5次/周与≤3次/月相比:0.49;95% CI: 0.25, 0.94)，但男性没有(调整后HR: 1.04;95% ci: 0.57, 1.90)。结论饮食尼古丁摄入量高的女性患PD的风险低于饮食尼古丁摄入量低的女性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

The American journal of clinical nutrition

自引率

0.00%

发文量