Method of controlling health safe levels of dimethyl dicarbonate content (DMDK, E-242) in the air of the working area

Abstract

Existing in Ukraine sanitary legislation on the introduction of chemicals into the national economy provides for compliance with regulations. Since the control over the presence of DMDK in the air of the working area is carried out only with the help of indicator paper, there was a need to develop a gas chromatographic method for its determination in the air of the working area by modeling the conditions of industrial use of the drug. Aim of the Research. To analyze research from available sources of information on the peculiarities of the use of dimethyldicarbonate (E 242, Velcorin), as well as regulations for its use and control. Materials and Methods. Review and analysis of scientific publications, directives and regulations of the EU. Gas chromatography method. Materials: silochrome C-120, fraction 0,35–0,5 mm according to TU 6-09-1748; KSK brand silica gel according to GOST 3956; glass wool according to the current ND; DMDK, analytical standard, 99,9%, CAS 4525-33-1; acetonitrile, Sigma-Aldrich No 34851. Computer data processing system and metrological evaluation of the methodology. Results and Discussion. The conducted research allowed to offer a modern method of determining the levels of DMDK in the air of the working area by concentrating it and detecting it by gas chromatography. The developed method allows to control compliance with the levels of DMDK content in the air of the working area in accordance with the requirements of GOST 12.1.016-79 “Air in the working area. Requirements for methods for measuring concentrations of harmful substances” at the level of ј the value of the hygienic standard. Conclusions. The proposed method of measuring the mass concentrations of DMDK is based on the use of gas chromatography using a flame ionization detector (FID). It allows to determine Velcorin in the range of mass concentrations from 0,1 to 0,5 mg/m3, the lower limit of its quantitative determination makes 0,1 mg/m3 at selection of 5 m3 of air. The relative standard deviation when using this method is 1,41%, the confidence limits of the random error — 0,04%, the total error of the measurement result — 12,24%, not exceeding + 25% and meeting the requirements of GOST 17.2.3.01-86. Keywords: dimethyldicarbonate, E242, Velcorin, air of the working area, gas chromatography method, indicator paper, ASLE, silochrome, flame ionization detector, sorption tubes, acetonitrile, chromatograms, metrological evaluation, concentration, detection.