Tumor with Aggregate Cells at the Level of Radial Distance Pipe - Treatment and Evolution

D. Tarnita, D. Grecu, M. C. Tenovici, R. Vaduva, A.D. Tudora, A. Grecu, I. L. Petrovici, B. Căpitănescu
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Abstract

Abstract A 20-year-old patient presented to the emergency service with radial distal epiphysis after a minor trauma. The radiological examination indicated a fracture at the radial distal epiphysis on the background of a tumor that occupied the radial epiphysis in its entirety, with cortical burglary in some places. When consulting the oncologist, a surgical intervention for biopsy material harvesting was performed. The anatomopathological exam showed: multiple fragments microscopically representing a tumor proliferation consisting of two cell populations, mononuclear cells, densely cellular and strobe pattern; areas of infarction, haemorrhage areas, rare intratumoral osteoid formation zones; appearance of giant cell tumor. The immunohistochemical examination confirmed the anatomopathological diagnosis adding, therefore, the aggressive character and the local relapse. The oncologist decided that it did not require oncology treatment but only orthopedic treatment. Orthopedic treatment required repeated surgery at intervals of about 5 months apart, caused by tumor recurrence. The first intervention consisted of 1/ 3 distal radius resection and replacement with a graft harvested from the peroneum. Tumor recurrence after 5 months required extirpation of tumor tissue and filling of caries caused in the graft with a fluid bone substitute. Recurrence after another 5 months required removal of the graft that was invaded by the tumor and cubitusmetacarpal arthrodesis fixed with a screw plate. Currently, the patient is undergoing complementary oncology treatment finally initiated by a medical oncologist.
细胞聚集在径向距离管水平的肿瘤-治疗和演变
摘要一位20岁的患者在轻微创伤后出现桡骨远端骨骺。放射学检查显示桡骨远端骨骺骨折,肿瘤占据了整个桡骨骨骺,并在一些地方出现皮质入室盗窃。当咨询肿瘤学家时,进行了活检材料采集的手术干预。解剖病理检查显示:多个碎片显微镜下代表肿瘤增生由两个细胞群组成,单个核细胞,密集细胞和频闪模式;梗死区、出血区、罕见的肿瘤内类骨形成区;巨细胞瘤的外观。免疫组织化学检查证实了解剖病理诊断,因此增加了侵袭性和局部复发。肿瘤学家认为不需要肿瘤治疗,只需要矫形治疗。由于肿瘤复发,骨科治疗需间隔约5个月重复手术。第一次干预包括1/ 3远端桡骨切除和腓骨移植物置换。5个月后肿瘤复发需要切除肿瘤组织并用液体骨替代物填充移植物引起的龋齿。5个月后复发需要切除被肿瘤侵袭的移植物,用螺钉板固定肘掌关节融合术。目前,患者正在接受补充肿瘤治疗,最终由内科肿瘤学家发起。
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