A study of the clinical factors correlate to glomerular filtration rate

Abstract

Objective To investigate the relative correlation between glomerular filtration rate(GFR) and various clinical factors and to offer theory basis for the measurement of GFR by the calculation method. Methods GFR of 50 cases of normal renal function group and 72 cases of renal insufficient group were determined using clearance of 99 Tc m-DTPA, and serum creatinine(SCr). Blood urea nitrogen, uric acid, serum potassium, sodium, calcium and hemoglobin were determined simultaneously; and heart rate, urine specific gravity, 24 h urine protein quantum, average artery pressure, body-weight index and body-surface area were determined simultaneously as well. Age and isotope dose for determining GFR were recorded. The simple correlation analysis of GFR in every group with different primary diseases to every other clinical factor above-mentioned were performed and the multiple correlation analysis of every clinical factor above-mentioned that were significantly correlated with GFR to GFR were performed again. Results For normal renal function group and renal insufficient group, correlation coefficient ( r ) between GFR and SCr were -0.449 and -0.275, respectively ( P0.05) . The correlations between GFR and other clinical factors were with different trends. Conclusion In renal insufficient patients with different primary diseases and normal renal function subjects the SCr is the ideal index for estimating GFR.