Research on a correlation between Cox-2 protein expression and the resistance of radiation therapy in esophageal squamous cell carcinoma

2011 IEEE International Symposium on IT in Medicine and Education Pub Date : 2011-12-01 DOI:10.1109/ITIME.2011.6132043

Hui Wu, Q. Fan

{"title":"Research on a correlation between Cox-2 protein expression and the resistance of radiation therapy in esophageal squamous cell carcinoma","authors":"Hui Wu, Q. Fan","doi":"10.1109/ITIME.2011.6132043","DOIUrl":null,"url":null,"abstract":"Objective To study a correlation between the resistance of radiation therapy in esophageal squamous cell carcinoma and Cox-2 protein expression for cancer organization before radiation therapy. Methods 76 cases were treated by pathology and confirmed the diagnosis of patients with esophageal squamous cell carcinoma, and all by radical radiation therapy for 6MV X-ray, illuminated the dose of 60 Gy. According to the radiation effect, they are divided into Radiation Resistance Group and Radiation Sensitive Group. Using the immunohistochemical SP method, these two groups of cancer organizations are given COX-2 detection and also contrast analysis. Results COX-2 protein expressions for esophageal squamous cell carcinoma in Radiation Resistance Group and sensitivity Group are 85.71% and 30.91%, Resistance Group is significantly higher than sensitivity group (P < 0.05). Conclusion In esophageal squamous cell carcinoma, high expression of COX-2 can cause tumors to resist the radiation, expression level of COX-2 can be regarded as an important index to predict radiation sensitivity of esophageal squamous cell carcinoma and short-term curative effect of radiation therapy.","PeriodicalId":170838,"journal":{"name":"2011 IEEE International Symposium on IT in Medicine and Education","volume":"146 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2011 IEEE International Symposium on IT in Medicine and Education","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ITIME.2011.6132043","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To study a correlation between the resistance of radiation therapy in esophageal squamous cell carcinoma and Cox-2 protein expression for cancer organization before radiation therapy. Methods 76 cases were treated by pathology and confirmed the diagnosis of patients with esophageal squamous cell carcinoma, and all by radical radiation therapy for 6MV X-ray, illuminated the dose of 60 Gy. According to the radiation effect, they are divided into Radiation Resistance Group and Radiation Sensitive Group. Using the immunohistochemical SP method, these two groups of cancer organizations are given COX-2 detection and also contrast analysis. Results COX-2 protein expressions for esophageal squamous cell carcinoma in Radiation Resistance Group and sensitivity Group are 85.71% and 30.91%, Resistance Group is significantly higher than sensitivity group (P < 0.05). Conclusion In esophageal squamous cell carcinoma, high expression of COX-2 can cause tumors to resist the radiation, expression level of COX-2 can be regarded as an important index to predict radiation sensitivity of esophageal squamous cell carcinoma and short-term curative effect of radiation therapy.

查看原文本刊更多论文

食管鳞状细胞癌中Cox-2蛋白表达与放疗耐药关系的研究

目的探讨食管鳞状细胞癌放射治疗耐药与放疗前癌组织Cox-2蛋白表达的关系。方法对76例经病理证实为食管鳞状细胞癌的患者进行根治性放疗，均采用6MV x线照射，照射剂量为60 Gy。根据辐射效应，将其分为抗辐射组和敏感辐射组。采用免疫组化SP法对两组癌组织进行COX-2检测并进行对比分析。结果放疗耐药组和敏感组食管鳞癌COX-2蛋白表达量分别为85.71%和30.91%，耐药组显著高于敏感组(P <0.05)。结论在食管鳞状细胞癌中，COX-2的高表达可引起肿瘤对放疗的抵抗，COX-2的表达水平可作为预测食管鳞状细胞癌放射敏感性及放疗短期疗效的重要指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

2011 IEEE International Symposium on IT in Medicine and Education

自引率

0.00%

发文量