Optimizing Fertility in Paediatric Disorders that Possess the Potential of Reducing Fertility and Maximization of Avoidance of Development of Male Infertility in Long Term: A Systematic Review

Abstract

Worldwide male factor Infertility contributes to 20-70% of couples attempting to conceive. Some male Pediatric generational disorders inclusive of Cryptorchidism, hypospadias, testicular besides other acquired cancers of childhood, infections, torsions, Spina Bifida along with Pediatric varicocoele have correlated with future infertility. Early timely fertility preservation, in particular in those waiting for chemotherapy or in cases of genetic disorders like Klinefelters syndrome (KS), Congenital Adrenal Hyperplasia need to be taken into account robustly in patients anticipated to generate testicular depletion. Despite no clarification regarding ideal timing in view of absence of long term prospective studies, early diagnosis as well as targeting treatment might cause maximization of fertility potential in adult hood. Here we conducted a systematic review utilizing search engine PubMed, Google Scholar; Web of Science; Embase; Cochrane review library utilizing the MeSH terms like Cryptorchidism; hypospadias, testicular cancers; torsion; other cancers of childhood; infections; Spina Bifida; paediatric varicocoele; Klinefelters syndrome (KS); Congenital Adrenal Hyperplasia from 1980’s till date in 2022. We found a total of 300 articles out of which we selected 97 articles for this review. No meta-analysis was done. Thus here we summarize how these disorders need to be tackled for optimizing long-term fertility potential.