Model studies of magnetic particle retention in the conducting airways

Abstract

This paper reports initial findings of using magnetic force to target and retain particles in airways using an ex vivo model, i.e. palate of bullfrogs (Rana catesbeiana). The purpose of this study was to investigate the feasibility of using magnetic force in targeted chemotherapy agents inhaled in an aerosolized form for lung cancer therapy. The results show that the clearance mechanism of airways will overcome magnetic force to clear aggregates of small particles (1-3 /spl mu/m) deposited, whereas aggregates of larger particles (180 /spl mu/m) can be retained at the targeted site when a magnetic strength of 80 mT and gradient of -6 T/m was used.