THE USE OF PROPOXAZEPAM FOR TREATMENT A SPECIFIC EPILEPTIC SYNDROME (PAROXYSMAL MANIFESTATIONS), WHICH IS ACHIEVED BY POLYMODAL MECHANISM OF ANTICONVULSANT ACTION: LITERATURE REVIEW OF OWN PRECLINICAL RESEARCH

Abstract

INTRODUCTION Epilepsy refers to chronic polyethyologic diseases of the brain characterized by recurrent seizures that occur as a result of excessive neuronal discharges and accompanied by various clinical and paraclinical symptoms. Anticonvulsant therapy remains the basis for treating patients with epilepsy, which involves inhibition or a significant reduction in the number of attacks 1 . Currently, the term antiepileptic are synonymous with anticonvulsant agents as they all selectively suppress seizure and their use is determined predominantly by the nature of paroxysmal manifestations or its equivalents. Depending on the clinical manifestations of epilepsy, different anticonvulsants can be prescribed. Often, for the treatment of epilepsy, combined use of several medicines is rational (simultaneously or sequentially). Therefore, the success of the treatment of epilepsy is on the way to finding new anticonvulsants, which would have had an effect on different pathogenetic links in the formation of all variability of seizure states. Antiepileptic drugs act on different molecular targets, selectively changing the excitability of neurons in such a way that the neuronal activity associated with attacks is blocked without disturbing the normal activity required to transmit signals between neurons. Various mechanisms can lead to reducing the excitability of the neurons of the epileptogenic cell. Basically they consist either in inhibiting activating neurons, or in activating depressing nerve cells, i.e., they are reduced to three major pharmaconeurophysiological effects 2 : relief of GABA or glycine-dependent transmission, reduction of excitatory (glutamate or aspartate) transmission