Interaction Mechanism and Technology for Application of New Ultra-Thin Drug Coating of Medical Biliary Stents

Abstract

Several years ago, there were no effective methods for treating bile tract structures, but the situation changed significantly with the invention of the stent. The use of biliary stents for the treatment of mechanical jaundice made it easier to remove them from the body. However, it was not possible to stop the appearance of restenosis and thrombosis. To prevent such complications, drug coatings, which are a polymer matrix with drugs introduced into it, began to be applied to the stent surface. At present, despite the rather wide range of drug coatings, the search for new biodegradable carrier polymers that provide a high-quality and inexpensive coating of biliary stents remains relevant. The paper considers the technology of creating a new ultra-thin drug coating for these stents based on polyvinylpyrrolidone with the addition of doxorubicin and carbon nanotubes. The invention proposes the use of carbon nanotubes based on their unique sorption properties. Steps of application of drug coating on stent surface and selection of optimal content of carbon nanotubes in coating composition are described. Theoretical studies of the interaction processes of drug coating components using the quantum-chemical method MNDO have been carried out. GAMESS, Gaussian, GaussView software packages were used for calculations.